Mannitol, a solution for infusions of 150 mg / ml

"Mannitol, a solution for infusions of 150 mg / ml" increases the osmolality of the plasma, causing fluid to move from the tissues to the vascular bed. It has a strong diuretic effect. The principle of diuretic action of the drug is that it is well filtered in the renal glomeruli, creates high osmotic pressure in the lumen of the renal tubules ("Mannitol" is slightly reabsorbed) and reduces the reabsorption of water.It operates mainly in the proximal tubules, although the effect is to some extent maintained in the descending loop of the nephron and in the collecting tubules.Unlike other osmotic diuretics, Mannit is able to remove a large amount of free water. Diuresis is accompanied by a significant release of sodium and chlorine without a significant effect on the excretion of potassium.It should be borne in mind that the sodium nasus that occurs when a drug "Mannit" is administered is less in magnitude than in water, which sometimes leads to hypernatremia. The drug does not significantly affect the acid-base state. The diuretic effect of the drug "Mannitol" depends on the amount of the drug filtered through the kidneys. The effect is all the more pronounced, the higher the concentration of the drug and the rate of its administration. If the filtration function of the renal glomeruli is impaired, the diuretic effect of the Mannitol solution may be absent.The drug is non-toxic, does not have antigenic and pyrogenic activity. Indications for use. Edema of the brain, cerebral hypertension, intensive therapy of convulsive state, ascites. Acute hepatic and renal failure with preserved filtration ability of the kidneys and other conditions that require increased diuresis: - status epilepticus, - acute attack of glaucoma, - operations with the use of extracorporeal circulation, - Post-transfusion complications after the introduction of incompatible blood, - poisoning with barbiturates and other poisoning.